PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.

Cyclic nucleotides (cAMP and cGMP) are the main second messengers linked to vasodilatation. They are synthesized by cyclases and degraded by different types of phosphodiesterases (PDE). The effect of PDE inhibition and cyclases stimulation on 5-hydroxytryptamine (5-HT; 1 microM) and histamine (10 microM) contracted arteries was analysed. Stimulation of guanylate cyclase or adenylate cyclase rel...

متن کامل

PDE4 and PDE5 regulate cyclic nucleotide contents and relaxing effects on carbachol-induced contraction in the bovine abomasum

The effects of various selective phosphodiesterase (PDE) inhibitors on carbachol (CCh)-induced contraction in the bovine abomasum were investigated. Various selective PDE inhibitors, vinpocetine (type 1), erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA, type 2), milrinone (type 3), Ro20-1724 (type 4), vardenafil (type 5), BRL-50481 (type 7) and BAY73-6691 (type 9), inhibited CCh-induced contraction...

متن کامل

Oxygen: influence on cyclic nucleotides and calcium sequestration in the human umbilical artery.

and Martha Vaughan, M.D. T he increase in O tension to which the human umbilical artery is exposed at birth acts in at least two separate but related ways to initiate closure of the vessel. Oxygen itself directly induces constriction.’ It plays further a “permissive” role in the action of other chemical agents that cause contraction.’ The relationship between elevated Po and contraction is beli...

متن کامل

Constriction of Human Umbilical Arteries

Experiments on perfused segments or isolated rings of human umbilical artery showed that the magnitude of their contraction in response to bradykinin, epinephrine, or serotonin depended on the P02 of the perfusing or bathing solution. Constriction to bradykinin varied directly with the O2 tension and was greatest when the Po2 was approximately that of umbilical arterial blood during the transit...

متن کامل

Proteoglycans of human umbilical cord arteries.

Proteoglycans (PGs) were dissociatively extracted from human umbilical cord arteries (UCAs) with 4 M guanidine hydrochloride containing Triton X-100 and protease inhibitors, purified by Q-Sepharose anion exchange chromatography and lyophilized. They were analysed by gel filtration, SDS/PAGE and agarose gel electrophoresis before and after treatment with chondroitinase ABC. It was found that the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: European Journal of Pharmacology

سال: 2008

ISSN: 0014-2999

DOI: 10.1016/j.ejphar.2007.12.017